Caleb Mccurdy Email & Phone Number

Boston, Ma, Us

This is an operational role, where I was responsible for protocol generation, creation of memos to assess INT DNA synthesis batches, on call support for manufacturing, and execution/transfer of studies from technical development to manufacturing. I also gained experience in a fast paced GMP environment, along with laboratory skills in DNA process, including assembly, transformation, prep, and sequencing.

Cambridge, Massachusetts, United States

In this role, I am working on LNP systems in collaboration with the rest of Delivery Science to investigate novel LNP formulations, processes, and analysis. I am gaining experience in LNP formulation, characterization, chemistry, SAXS, HPLC, CryoEM, and nanoFCM.

Norwood, Massachusetts, United States

On the Bioassay team I developed an alternative ELISA method for potency testing using ready to use cells plated and transfected straight out of cryofreeze. This significantly reduced the assay time and allowed for a safeguard in case a passaged cell line went down. I also worked hard on assay prequalification, routine sample testing using ELISA and CFT assay techniques, and was in charge of cell passaging and plating for one of the cell lines used by the group.

Ithaca, New York, United States

I worked on mRNA in vitro transcription and lipid nanoparticle (LNP) formulation to investigate the mRNA translational efficiencies with modified vs unmodified nucleotides in vivo studies. I also created a microfluidic chip using photolithography at the Cornell nanofabrication center to assist in high throughput LNP production. Additionally, I was the lead on producing mRNA LNP systems for our collaborator at Weill Cornell Medical College for ongoing vaccine studies. I routinely performed transformations, maxiprep, PCR, imaging, mouse surgeries/injections, and LNP characterization.

Worked on the F. nucleatum vaccine to treat colorectal cancer. I gained experience doing cell culture of 293T and 3T3 cells, transfections, PCRs, gel electrophoresis, transformations, maxiprep, mouse surgeries, proteomics, and designing experiments.

Richmond, Virginia, United States

In this position I designed, simulated, and built microfluidic chips to investigate the progression, treatment, and cause of degenerate intervertebral disks.