Christopher Carroll Email & Phone Number

Sweden

Lund, Skåne County, Sweden

• Spearheaded the coordination of impactful events and strategic marketing campaigns• Acted as a liaison between laboratories and Proteintech, fostering scientific communication• Authored informative technical blogs focused on molecular biology techniques

Lund, Skane County, Sweden

My role at the Department of Translational Medicine in Lund University has involved me working across Sweden, UK, US, and Denmark in several different key projects such as:1) Hypoxia Generated by Avian Embryo Growth Induces the HIF-α Response and Critical Vascularization2) Cisplatin resistance vis HIF2a and AP1 singalling. 3) Multicellularity, biomineralization and their regulation by circadian CLOCK4) Targeting ATF3 signalling in response to radiotherapy.Other tasks include:5) Co-supervision of undergraduate and Ph.D students (3 undergraduate students , 2 Ph.D students)6) Key contact person for protein based experiments within the Tissue Development and Evolution labs in multiple model organism systems.7) Superuser of XenX and chemidoc systems8) Generation of CRISPR Knockouts, Knockins, and CRISPRi in multiple cell lines, targets, and species.

Netherlands

Training in the generation of Single Cell Whole Genome Sequencing datasets.

Nottingham, United Kingdom

Main Project: Targeting hypoxia regulated sodium driven bicarbonate transporters (NDBT) to reduce breast cancer metastasisUndertook a research project into the molecular mechanisms of pH regulation, hypoxia, and cancer metastasis. The project involved investigating changes at: epigenetic, transcriptional, protein, and function levels. Fusion proteins were produced to determine binding partners assays and co-localisation. In vitro migration and invasion assays were performed; as well in vivo experimentation to determine the effect upon metastasis. Mechanistic investigations determined that NDBT knockdown or inhibition reduced mTOR activation and HIF-1 stabilization in hypoxia. This culmiated in a loss of EMT induction in knockdown cells. Furthermore, metablomics and metabolism based assays were performed to determine the effect on ATP production, lacatate, ROS levels, and mitochondrial copy number and function. Side project 1: Sound based imaging techniques for cancer biologySide Project 2: Cancer cell evolution and cellular plasticity

Stevenage, United Kingdom

Contracted to work for GSK within the High Throughput Expression and Characterization group. Undertook protein analytics within Biopharm discovery to characterize antibodies for multiple projects and feed back results to project teams. This required the bespoke designing of each assay for each project or piece of data required. Tasks included epitope binning, active protein concentration quantification, affinity and kinetics determination, single shot binding screens, LC-Mass spec, and size exclusion chromatography etc. This was primarily performed using Biacore and Octet. Adittionally, MSD-SET assays were also performed.

Alderely Park

Contracted to work for by VWR Catalyst as a research technician in Oncology iMED. Required to ensure the smooth operation of the high throughput screening of novel small molecule inhibitors in the search for synergistic effect. This project required the maintenance of 250 cell lines from a plethora of tissue types and correct dosing of 50 different compounds in a 384 plate well format. Automated systems used include Acumen and echo. The data was analysed using genedata, spotfire and other analysis packages

Stockport, United Kingdom

Undertook a variety of tasks ensuring the smooth running of the Whole Cohort SNPs genotyping project (WCSG). This included quality control testing, DNA extraction and preparation, and also process validation. In addition, I also edited standard operating procedures, performed molecular biology assays, and used robotic systems whilst ensuring all data was properly logged in LIMS.

Preston, United Kingdom

General cleaning and maintenance of working, serving and communal/social areas. In addition I was required to regularly check, maintain, and replenish existing stock.

Doctor Of Philosophy - Phd, Oncology And Cancer Biology

Master Of Science (Msc), Oncology And Cancer Biology, Merit

Activities and Societies: Trampolining, Muay Thai Masters course encompassing a large array of disciplines aimed at developing a well.

Bachelor Of Science (B.Sc.), Human Biology, 2.1

Activities and Societies: Labour party, Snowsports Undergraduate degree encompassing multiple areas within the field of life-sciences. I.

Undergraduate Credits, Cell/Cellular And Molecular Biology, 3.0

Activities and Societies: Biology society, Model United Nations Second year of my undergraduate degree studied abroad as an exchange.