Dmitry Zaretsky Email & Phone Number

• Discovered
• Amyloid degradation toxicity hypothesis of the etiology and pathogenesis of Alzheimer's disease;
• Novel pharmacological targets for a treatment of neurodegenerative diseases;
• High throughput technique for target validation and for screening drugs to prevent/treat Alzheimer’s disease.

Research Triangle

• Developed and established rodent models for preclinical studies;
• Designed, planned, and executed PK, MTD, and PK/PD studies for candidate selection.

Research Triangle Park, NC

• Led research and discovery studies of biologically active peptides with metabolic, cardiovascular, and endocrine end-points;
• Developed and performed functional assays for candidate selection;
• Participated in new target selection;
• Prepared white papers on liabilities and new use of current and pipeline company products.

Indianapolis, IN

• Studied the neurophysiological mechanisms mediating metabolic, autonomic and behavioral changes in various paradigms with the focus on stress, exercise, and the use of psychostimulants.
• Developed a multiscale model of multiphasic responses to amphetamines;
• Developed a model of thermoregulation during the exercise;
• Proved that locomotion is critical for the fatal hyperthermia after MDMA in hot conditions;
• Demonstrated the role of dorsomedial hypothalamus in various paradigms.
• Found the brainstem relay between hypothalamus and spinal cord in stress circuitry;

Moscow, Russian Federation

• Studied hypothalamic monoaminergic mechanisms of stress;
• Supervised projects with animal models of cardiovascular diseases (hypertension, congestive heart failure, stress sensitivity);
• Large scale animal study of genetic traits in hereditary hypertension.

Moscow, Russian Federation

• Teaching Pharmacology for medical students;
• Mentoring research projects of medical students;
• Secretary-in-Charge of Admission Committee of the Medical School.

Moscow, Russia

• Developed educational software for elementary schools:
• Design and programming;
• Project management;
• Authored textbooks for students and teachers (60,000+ copies);
• Performed and published research on the use of the software in schools;
• Trained end-users. Projects:

Moscow, Russian Federation

• Teaching Molecular Pharmacology for medical students;
• Mentoring research projects of medical students.

Doctor Of Medicine (M.D.), Medical Biophysics, With Distinction

Doctor Of Philosophy (Phd), Educational/Instructional Technology