Eloy Hernandez Email & Phone Number

San Diego, Ca, Us

San Diego, California, United States

San Diego, California

Identified and interrogate 2 anti-inflammatory and 16 anti-fibrotic diseases.Developed and successfully executed in vitro pharmacology assays to identify siRNA assets as candidate compounds for the previous targetsDesigned in vitro and pre-clinical studies to determine efficacy of small molecules and siRNA assets (LNP and GalNac) to progress the next clinical stage.Successfully progressed 1 anti-inflammatory and 3 anti-fibrotic targets form early discovery phase into clinical development.Acted as a cross-functional team player and leader for the progression of my projects, and actively take decisions to in-license an external company compound to go directly into Clinical Phase 2b.Managed 1 junior Scientist Assistant who was promoted due to my mentorship to Research Associate Scientist in less than a year. Mentoring junior staff in our group (from interns to Scientist II)

La Jolla, California

Expertise in fibrosis driving projects from concept to advance stagesLead the discovery of the Mechanism of Action (MoA) of the MASH FXR agonists Flagships of Novartis (Tropifexor and Nidufexor) Lead the biology and PD biomarker identification of 1 anti-fibrotic target to be ready for clinical development. Designed, optimized and executed a successful phenotypic high-throughput screen using CRISPR technology in primary liver cells to identify more than 10 genetic drivers of hepatic stellate cell activationDevelop complex in vitro assays, incorporating biophysical properties of the extracellular matrix.

San Diego County, California, United States

Identified the mechanism of action of NBR1 in macrophage M1 polarization in obesity, as a target to improve insulin sensitivity in Type 2 DiabeticsIdentified the critical role of SQSTSM1 (p62) in the tumor microenvironment as target to reduce de progression to HCC and PDAC in patients.

Madrid, Madrid, Spain

Experience in inflammatory disease: Reumathoid arthritis, Celiac disease and NFkB pathway analysisDevelopment of microbiota analysis identification

Madrid

Characterization of the regulatory promoter of glycolytic enzyme phosphofructokinase isoforms C and L.

Madrid Area, Spain

Internship in the Drug Discovery area of PharmaMar pharmaceutical company. I have participated in the HTS of new drugs in the department of celular biology performing cellular assays for the discovery of HDAC inhibitors.

Phd In Biochemistry And Molecular Biology, Biology/Biological Sciences, General

Activities and Societies: From 2008 to 2010 I have participated in the biochemistry department council of the school of medicine (UAM).

Bachelor Of Science - Bs, Biology/Biological Sciences, General

Colaboración en el Departamento de Microbiología y Parasitología de la Universidad de Alcalá en la línea de investigación “Enzimas.