A highly skilled and team-oriented senior scientist in gene therapy with 15 years of experience in ocular research and development. Pre-clinical research includes multiple disease areas including retinitis pigmentosa, age-related macular degeneration, and glaucoma across multiple routes of administration including sub-retinal (SR), intravitreal (IVT) and suprachoroidal (SCS) delivery. Pharmaceutical industry experience includes research project management with direct CRO and contractor management with the goal of IND enabling data, development of IVT and SCS platforms, in vivo testing of viral (AAV) and non-viral (lipid and polymer-based nanoparticles) gene therapy vectors, team lead for ELN (Benchling) implementation, and internal in vivo ocular team surgical and imaging training. Species expertise includes mice, minipig and non-human primates with extensive in-life data interpretation and analysis.
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Move FellowHandshakePhiladelphia, Pa, Us -
Senior Research ScientistSpark Therapeutics, Inc. Nov 2020 - PresentPhiladelphia, Pennsylvania, United StatesLed a program exploring non-viral vectors for ocular gene delivery including LNP and polymer-based nanoparticles. Integral part of a team that established multiple routes of administration for viral vectors in the eye including intravitreal and suprachoroidal delivery. Led a program establishing a novel non-human primate model of wet age-related macular degeneration. -
Adjunct InstructorIvy Tech Community College Aug 2016 - Dec 2020SellersburgInstructor for 14 sections of Anatomy and Physiology I/II and 1 section of Biology 101 with consistently excellent anonymous student reviews each semester (4.8+ on a 5 point scale for nearly every measure). -
Senior Research AssociateUniversity Of Louisville School Of Medicine Jun 2019 - Sep 2020Louisville, Kentucky AreaLed a program exploring genetic (AAV delivered endonuclease) or molecular treatments (anti-sense oligonucleotides, small molecules) for blinding eye disease in a large animal model of autosomal dominant retinitis pigmentosa (Tg-P23H miniswine). -
Postdoctoral ResearcherUniversity Of Louisville School Of Medicine Jul 2014 - Jun 2019Louisville, KyLed a project exploring the mechanisms of direction selectivity in mouse starburst amacrine cells through patch-clamp and two-photon calcium imaging. This work was the first direct evidence of bipolar cell excitatory input driving direction selectivity without requiring inhibitory input to starburst amacrine cells. -
Postdoctoral FellowUniversity Of Louisville School Of Medicine Jul 2013 - Jun 2014Louisville, KyI received a T32 grant through the Institute for Cellular Therapeutics (ICT) under the NIH Ruth Kirchensteiner program to lead a project exploring photoreceptor precursor cell transplantation in the P23H-Rho mini-swine model.
James Fransen Education Details
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Retina Physiology In The Dept Of Anatomical Sciences And Neurobiology -
Anatomical Sciences -
Biology/Biological Sciences, General
Frequently Asked Questions about James Fransen
What company does James Fransen work for?
James Fransen works for Handshake
What is James Fransen's role at the current company?
James Fransen's current role is Move Fellow.
What schools did James Fransen attend?
James Fransen attended University Of Louisville School Of Medicine, Northern Illinois University, University Of Illinois At Urbana-Champaign.
Who are James Fransen's colleagues?
James Fransen's colleagues are Jodi Mcbride, Noma Mpofu, Taahir Hutchings, Kate Nardini, Himali P., Renee Gentzel, Shana Boyer.
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James Fransen
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