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I am a Cancer Cell Biologist and Immunologist with primary experience in patient-derived models of cancer (PDMCs) and clinical informatics. I currently oversee generation, validation and drug-response assays of PDMCs including cell lines, 3D models with cell lines, organoids, and patient-derived xenografts for OHSU's participation in a U01 Consortium on Patient-Derived Models of Cancer. I additionally focus on clinical case studies of patients with exceptionally positive outcomes after diagnosis with pancreatic adenocarcinoma. To facilitate these research interests, I have created and maintain a database that connects specimen- and PDMC-level results (e.g., gene-expression-based subtypes, genomic alterations, leukocyte densities, drug responses, etc) with robust clinical data I have collected and curated from patients with pancreatic adenocarcinoma. This database has allowed our group to identify relationships between newly-defined clinical cohorts, outcomes, and disease characteristics. Research Interests: Pancreatic Cancer, Lymphoma, PDXs, Organoids, Cell Lines, Patient-Dervied Models of Cancer, Drug Discovery, MYC-Mediated Oncogenesis, Cancer Cell Biology, Immunology, Tumor Immunity, Autoimmunity, Cell Metabolism
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Research Assistant ProfessorOhsu | Oregon Health & Science University Dec 2014 - Feb 2022At the Brenden-Colson Center for Pancreatic Care at OHSU, I initiated and oversaw the generation and validation of multiple patient-derived models of cancer, and I collected and curated clinical information into a database that connects disease progression in patients to myriad features of pancreatic tumors. A primary goal of my work was to support future precision oncology by rapidly deciphering molecular features of tumor cells and the tumor microenvironment and connecting this data to patient outcomes. -
Research FellowShriners Hospitals For Children Apr 2008 - Sep 2013Portland, Oregon AreaAt the Knight Cancer Institute and Shriners Hospital I completed a major project to identify the physiological purpose of Mnt (a Myc-oncogene family member). I used a series of novel transgenic and knockout mouse models to demonstrate that Mnt supports oncogenesis and is a viable target for cancer therapeutics.Link JM and Hurlin PJ (2013) MYC needs MNT. Cell Cycle. 12(3):385-6.Link JM, Ota S, Zhou ZQ, Daniel CJ, Sears RC, Hurlin PJ (2012). A critical role for Mnt in Myc-driven T cell proliferation and oncogenesis. Proc Natl Acad Sci USA. 109(48):19685–19690. -
Associate InvestigatorPortland Veterans Affairs Medical Center Feb 2006 - Feb 2008Portland, Oregon AreaAt the Portland VA Medical Center I made essential academic and technical contributions to a successful IND application for a drug that recently completed Phase 1 clinical trials. Specifically, I published pre-clinical drug efficacy and safety results of a Multiple Sclerosis drug (RTL1000) as the primary author. Additionally, I determined the minimum effective dose and maximum tolerated dose in humanized mouse models, and I developed the techniques needed to identify the drug in serum and antibodies raised against it.
Jason Link Skills
Jason Link Education Details
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Microbiology/Immunology -
Biology
Frequently Asked Questions about Jason Link
What is Jason Link's email address?
Jason Link's email address is li****@****hsu.edu
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What schools did Jason Link attend?
Jason Link attended University Of Alabama At Birmingham, Willamette University.
What skills is Jason Link known for?
Jason Link has skills like Exploiting Metabolic Weaknesses In Cancer Cells, Cancer Cell Metabolism, Cancer Research, In Vivo Oncology, Drug Development, Drug Discovery, Immunology, Multi Color Flow Cytometry, Animal Models Of Human Disease, Molecular Biology, Life Sciences, Western Blotting.
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Jason Link
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