As a bioinformatics leader since 1990, I direct the Saccharomyces Genome Database (SGD) and manage teams in developing databases and ontologies, enhancing the integration and accessibility of biological data. My role includes leading projects like the NIH ENCODE Data Coordination Center and the Gene Ontology Consortium, focusing on data curation, consistency, and public distribution. Recently, my group has joined the Human Cell Atlas project, contributing to data operations, curation, and outreach in mapping human cells.