Currently project coordinator for two projects.-The Decommissioning Steriles CO project. The goal of this project is to decommission the equipment of the former Steriles department and to make the facilities available for new opportunities.-Project to introduce a safe way to exchange the main HVAC exhaust filters and to improve automatic start/stop and interruption of the HVAC of the IPT Solids departmentFrom May 2016 until May 2019 projectcoördinator for the projects to upgrade the HVAC and Dust Collection systems of the Solids department of Pharmaceutical Operations. The upgrade has to be realized with minimal interruption of the operation. Phasing and in detail preparation are the key words for these projects.Conceptual design to upgrade purified water (PW) installation of the Solids department.

Projectleader for defining and realization of the supply of 100 % ethanol and 33% caustic Soda to the Biotech facilities of MSD and the collection of waste ethanol of these facilities.Projectleader for relocation of freezing small drug substance samples towards the down stream production faciliy and realizing the cold chain of the frozen samples.

For the extension of the production capacity of Implanon NXT (MSD product) production activities and equipment need to be tranferred to other locations. In this way production areas are made available for Implanon NXT production facilities and equipment. The relocation is executed in phases. Within the scope of the team milling/sieving-, extrusion-, big bag unloading- and cleaning equipment of different Production departments are to be relocated. The team is responsible for the decommissioning at the existing location, the disconnection of the equipment, the transport, the installation, commissioning, qualification and making the equipment ready for use at the new location. Parallel to the transfer the concerned equipment is going to be prepared for contained handling of Active Pharmaceutical Ingredients (API's).GMP, EHS and operational risks are to be minimized. Risk assessments are executed for this.The team is also responsible for execution under change control the modifications towards the existing Environmental Management Systems and to introduce under change control the modifications in the material flows during and after the construction activities needed.

Conceptual design and feasibility study of two flow wrapping machine directly connected to a blister machine.In the current situation blistermachine and three separate flow wrapping machines are used.The purpose is to reduce the handling of products, to reduce the lead time and to solve ergonomic issues in the existing situation.The study has been finalised and accepted by the MSD management. The decision was taken to introduce the new concept. This is stopped to investigate other possibilities to optimize the production process.

Within the existing production facility of IPT Solids Women Health and Other Franchises deparments of Pharmaceutical Operation Oss at MSD in Oss a Purified water storage (5 m3) and distribution loop has been introduced. The interface with existing CIP systems have been realized. The project has been realized from conceptual deign until and including qualification.Total length of the distribution loop is approximately 250 m.Number of automatic Point of Uses: 7Number of manual Point of Uses: 8

Successfull execution of green belt project. Project has been executed with a team of operators of the IPT Solids department of Pharmaceutical Operation Oss (POO) of MSD in Oss.Since April 2012 I am certified as Six Sigma-Greenbelt by Maruna Process Improvement.Green belt has been executed while I was working as project manager from Yxion at MSD in Oss.MSD made it possible that I could done a six-sigma project. Training at Maruna has been arranged by Yxion.

Per April 1 2009 I did this work under responsibility of Yxion.New welding machine Assembly MachineIn cooperation with CMC a new ultrasonic "welding" device for the assembly machine of Implanon (MSD product) Applicator has been introduced.Extensive tests were exeucted to show the process capabilities of the system and to reduce the risk of the introduction of a new welding machine.Introduction has been done succesfully. The robustness of the machine has been improved.Contained transfer of Active Pharmaceutical Ingredients (API)For the IPT Steriles CP department the transport and transfer of API's in a disposable contained system (Hicoflex) has been introduced. Including all test to proof the system was suitable for this application. A method to fill the disposable with API has been developedFor the IPT Nuvaring department the transport and transfer of API's in a stainless steel container with Split Butterfly Valve has been introduced.Reduction safety risks due to working with hoisted containers above compression machines.Support frames over the compression machines have been introduced. On this frames the containers are to be placed. The introduction has been done in close cooperation with the operators working with the machines. In total 7 frames have been introduced.

Supervisor of Utility Mechanical Engineering. Group of 12 employees educated on Bachelor or Master level. Responsible for the quality level and further development of the group.Project manager of Membrane Bio Reactor (2.3 M€), Conditioned Drum Warehouse (700 k€) and AD cooling project (600 k€). Chairman of several HAZOP studies. Responsible for the creation of the Explosion Protection Document (ATEX) of the offset plate factory. Responible for the set up of the Management of change procedure as part of the BRZO (Dutch: Besluit Risico Zware Ongevallen) law.

Execution of a wide varity of projects to modify existing production installations. In this way these installations have been made suitable for new type of products, have been increased in capacity and/or have been made in line with changed safety requirements.P2PK rpoject: reshape of the photo film plant to make it suitable for the production of litho film. Project budget: 21 Mfl. Multi discipline project with modifications in the process control software and hardware, chemical production lines and the web-handling. Modifications have been executed within the scheduled time (8 months) and budget.

Responsible for the modification in the chemical plant, web-handling speed-up, electro charging equipment etc.

Responsible for the availability of the Coating department of the photo paper factory. Supervisor of team secondary school, bachelor and master level educated mechanical and electrical engineers. Photo paper factory had to run 24 hours a day, 7 days a week.

Preparation and coordination of the maintenance activities during maintenance days, construction stops and breakdowns. Initiation and realisation of reliability improvements.

Centre for Manufacturing Technology (CFT)Dynamics of Production Systems (1988-1989). Advises about set up of production systems within Philips factories.Robot Apllication Group (1985-1988)Reponsible for gathering and the transfer of knowledge and experiences with industrial robots.

Responsible for th set up of a compltely automated (robotised) assembly of small magnetic valves.