Development of drugs for vascular stabilization and GI disease

Pharmaceutical Development of products for anemia and vascular disease

Will retire from The Procter & Gamble Company on December 31, 2008 after 30 years of service in R&D. Long-term experience in leading diverse chemistry teams (3-10 chemists) and project teams (15-30 scientists) at all stages of the pharmaceutical discovery process. Career-long experience in correlating chemical structure with activity for use in pharmaceutical, food, and oral care applications. Leader of a very active problem solving program serving all business areas.Two+ years of pharmaceutical experience as a member of the Search & Evaluate group in Pharmaceuticals supporting the in-licensing of gastrointestinal and antiinflammatory drugs.Four years of recent and ongoing university teaching experience.Expertise: Organic Chemistry, Medicinal Chemistry, Structure-Activity, Drug Design, Antiinflammatory and Antiarrhythmic Drugs, Sweeteners, Technical Management, Technical Assessments, In-licensing, Out-licensing, Patent Assessments, Ph.D.Recruiting, University Teaching

1991 - 2008 P&G PharmaceuticalsChemical Development: Coordinated internal and external synthesis of compounds for health careIn-licensing: Assessed opportunities in gastrointestinal and inflammation focus areas Discovery: Led a multidisciplinary team targeting atrial-selective antiarrhythmics through preclinical safty assessment. Project was successfully out-licensed. Led teams targeting inhibition of cardiac reperfusion injury and antiarrhythmic compounds with heart rate-dependent activity. Led synthesis/development of COX-2-selective dual cyclooxygenase/lipoxygenase (COX-2/5-LOX) inhibitors as stomach-safe antiinflammatories. 1978-1991 Procter & GambleSynthesized tartar and gingivitis control agents; prepared dipeptide sweeteners with better stability and potency than Aspartame; Identified clinical candidate “Olvanil” for pain control2005 - 2008 Adjunct Professor of Chemistry, The University of Cincinnati and Xavier University: