Jon Rosen Email & Phone Number

San Diego, CA, US

Greater San Diego Area

La Jolla, CA

Leading drug discovery effort designed to target host proteins involved in viral replication based on genome-wide siRNA screens.

• Line management responsibility for the Pharmacology, Lead Discovery and Molecular and Cell Biology groups and all biology efforts related to ongoing drug discovery efforts at Exelixis San Diego
• Responsible for new target evaluation at Exelixis San Diego
• Initiated and established new discovery programs with varied target classes that successfully resulted in clinical candidates
• Project leader for S1P1 receptor program (inflammation, MS) that was partnered with BI based on program results
• Project leader for multiple programs targeting type 2 diabetes targets that identified development candidates for two programs
• Initiated additional discovery efforts targeting autoimmune disease

• Leader of the cytokine receptor / ‘JAK/Stat’ research platform in-licensed from Darnell lab at Rockefeller Universityo Led to a collaboration with GSK (at that time SB) on hematopoietic growth factors. During the.
• Androgen receptor (AR) program leader aimed at the discovery of selective androgen agonists to treat diseases resulting from low testosterone levels and antagonists for prostate cancer
• Initial project leader for selective glucocorticoid receptor project designed to identify GR modulators for inflammatory disease. Partnered with Abbott.
• Established a new oncology/prostate cancer effort targeting hedgehog to take advantage of ongoing pharmacology models in the prostate cancer area used to characterize AR antagonists.
• Involved in in-licensing and out-licensing multiple research programs

• Line management responsibility for biology group
• Led HIV project designed to exploit synthetic peptides for diagnostics and therapy
• Designed and constructed chimeric hematopoietic growth factor proteins to enhance activity
• As part of J&J collaboration with Scripps Research Institute, was a primary reviewer of Scripps technology for utility within J&J

Ph.D/, Microbiology

Bachelor Of Arts (B.A.), Biology, General