Jorge Quintero Email and Phone Number
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An innovative and accomplished medicinal chemist with extensive experience in hit-to-lead, lead optimization, and pre-development programs across multiple target classes, including infectious diseases (viral and bacterial), immunomodulators, kinases, and GPCRs. Skilled in designing and developing efficient syntheses for a broad range of biologically active small molecules. Extensive bench experience in heterocyclic small molecule synthesis ranging from milligram to gram-scale quantities. Well-versed in high throughput chemistry techniques, including parallel library preparation. Highly proficient in regular and reversed-phase purification techniques like (ISCO), Gilson, preparative HPLC, preparative TLC, re-crystallization, and in-compound characterization, including 1D and 2D NMR, LC, and LCMS analysis and interpretation. Proficient with Parr hydrogenators, microwave-assisted organic synthesis (MAOS), and Electronic Notebook (ChemCart ELN).
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Senior Scientist, ChemistryNj Bio, Inc. Feb 2024 - PresentPrinceton, New Jersey, United States
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Scientist ChemistryArbutus Biopharma Corporation Nov 2016 - Nov 2023Warminster, Pa• Conducted medicinal chemistry research on several programs targeting a combination cure for Hepatitis B including: Capsid Assembly Modulators (CAMs), agents providing S-Antigen (HBsAg) reduction, PD-L1 Interference (currently in Phase 1 clinical studies), and cccDNA formation inhibition. • Executed structure activity relationship (SAR) studies through extensive iterative analog synthesis and data interpretation, conducting syntheses from milligram to multigram scale. • Designed and synthesized multiple advanced leads for late-stage profiling as potential Development Candidates for the Capsid Assembly Modulator and PD-L1 programs. -
Research Associate, Medicinal ChemistryVenenum Biodesign 2010 - Nov 2016Hamilton, New Jersey, United States• Synthesized 800-member solution-phase parallel library of Beta-Sheet mimics employing high throughput chemistry techniques involving the use of scavenger resins and phase transfer catalysts. • Conducted medicinal chemistry optimization of small-molecule non-antibiotic inhibitors of the Clostridiodes difficile (C. diff.) toxin enzymes (TcdA/B) as potential C. diff. anti-infective agents.
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Scientist, Medicinal ChemistryLigand Pharmaceuticals Dec 2008 - Jun 2010Cranbury, New Jersey, United States• Designed and synthesized sub-nanomolar, selective tri-substituted purinone compounds as JAK3 kinase inhibitors for rheumatoid arthritis, in collaboration with Wyeth/Pfizer. • Synthesized multi-gram quantities of key JAK3 inhibitors allowing the demonstration of oral efficacy in a mouse CIA model. • Independently developed and optimized novel synthetic pathways towards intermediates and targets. Transferred optimized procedures to CRO’s and scale-up groups. -
Scientist, Medicinal ChemistryPharmacopeia Jan 1998 - Dec 2008Cranbury, New Jersey, United States• Synthesized benzodiazepinediones for Germ Cell Nuclear Factor (GCNF) modulator program, involving 4-6 step solid-phase synthesis including aza-Wittig cyclization reactions, and 2-3 step synthesis of custom synthons via Suzuki couplings and generation of custom boronates. • Synthesized substituted pyrimidine compounds for Bradykinin (BK1) antagonist program (including gram scale for in vivo testing). Chemistry routinely involved separation of both regioisomers and diastereomers. Chemistry included solution phase and solid phase syntheses, as well as preparing custom amino acids.
Jorge Quintero Skills
Jorge Quintero Education Details
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Organic Chemistry -
Chemistry
Frequently Asked Questions about Jorge Quintero
What company does Jorge Quintero work for?
Jorge Quintero works for Nj Bio, Inc.
What is Jorge Quintero's role at the current company?
Jorge Quintero's current role is Experienced Synthetic Organic Medicinal Chemist with extensive experience working with small molecules, with target classes including Antivirals, Antibacterials, Immune Modulators, Kinases and GPCR's..
What is Jorge Quintero's email address?
Jorge Quintero's email address is jo****@****ail.com
What is Jorge Quintero's direct phone number?
Jorge Quintero's direct phone number is +173240*****
What schools did Jorge Quintero attend?
Jorge Quintero attended Seton Hall University, Saint Peter's University.
What skills is Jorge Quintero known for?
Jorge Quintero has skills like Medicinal Chemistry, Chemistry, Drug Discovery, Lifesciences, Lc Ms, Lead Change, High Throughput Screening, Hplc, Organic Chemistry, Biotechnology, Laboratory, Biochemistry.
Who are Jorge Quintero's colleagues?
Jorge Quintero's colleagues are Dipti Baraskar, Chun-Min Zeng, Padma Chaurasia, Yogesh Aeer, Appi Reddy Mandhapati, Kurt Hines-Williams, Gajanan Thakre.
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Jorge Quintero
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Jorge Quintero
Fort Lauderdale, Fl4peer1.com, icloud.com, hotmail.com, aptum.com7 +121361XXXXX
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