Mark Tye
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Mark Tye Email & Phone Number

Medicinal Chemist at Revolution Medicines at REVOLUTION Medicines
Location: San Ramon, California, United States 8 work roles 2 schools
1 work email found @harvard.edu LinkedIn matched
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Work email m****@harvard.edu
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Current company
REVOLUTION Medicines
Role
Medicinal Chemist at Revolution Medicines
Location
San Ramon, California, United States
Company size
116 employees

Who is Mark Tye? Overview

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Quick answer

Mark Tye is listed as Medicinal Chemist at Revolution Medicines at REVOLUTION Medicines, a company with 116 employees, based in San Ramon, California, United States. AeroLeads shows a work email signal at harvard.edu and a matched LinkedIn profile for Mark Tye.

Mark Tye previously worked as Scientist 2 - Medicinal Chemistry at Revolution Medicines and Scientist 1 - Medicinal Chemistry at Revolution Medicines. Mark Tye holds Doctor Of Philosophy - Phd, Chemical Biology from Harvard University.

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{first}_{last}@harvard.edu
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Profile bio

About Mark Tye

I am a passionate medicinal chemist working on the RAS/MAPK pathway. During my Ph.D. in Chemical Biology at Harvard University, I worked in the Mazitschek group on an integrated chemogenomic approach exploring and exploiting prolyl-tRNA synthetase (ProRS) as target for next-generation malaria and cancer therapies. As part of this, I designed a diverse set of high affinity inhibitors, including the first triple-site ligands for any aminoacyl-tRNA synthetase (aaRS) enzyme that simultaneously engage all three substrate-binding pockets. Guided by the SAR data from my inhibitors and representative co-crystal structures, I overcame existing technology limitations by developing the first Time-Resolved Förster Resonance Energy Transfer (TR-FRET) based aaRS ligand displacement assay platform for direct biochemical characterization of ProRS ligands, including substrate competitiveness and binding kinetics. During my undergraduate studies, I worked in the Francis group at U.C. Berkeley developing and implementing new bioconjugation chemistry for targeted drug delivery of photodynamic therapy agents using a modified MS2 virus capsid in order to treat phytopathogenic fungi.

Listed skills include Chemistry, Organic Chemistry, Hplc, Biology, and 10 others.

Current workplace

Mark Tye's current company

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REVOLUTION Medicines
Revolution Medicines
Medicinal Chemist at Revolution Medicines
redwood city, california, united states
Website
revolutionmedicines.com
Employees
116
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8 roles · 10 years

Mark Tye work experience

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Scientist 2 - Medicinal Chemistry

Current
Revolution Medicines

Redwood City, California, United States

  • Lead Chemist for KRAS G13D program
  • Managed 1 direct report (MS)
  • Managed CRO team (55 FTEs)
Aug 2023 - Present

Scientist 1 - Medicinal Chemistry

Revolution Medicines

Redwood City, California, United States

  • Lead Chemist for KRAS G13D program
  • Managed 1 direct report (MS)
  • Managed CRO team (55 FTEs)
Sep 2022 - Aug 2023

Ph.D. Student

Harvard University

Cambridge, Massachusetts

Chemical Biology Ph.D. in Dr. Ralph Mazitschek's lab.Dissertation: Development and mechanistic characterization of prolyl-tRNA synthetase inhibitors as next generation antimalarials and chemotherapeutics. To assist with this, developed homogeneous, single-step TR-FRET (Time-Resolved Forster Resonance Energy Transfer) assay for characterizing Plasmodium and.

2016 - 2022 ~6 yrs

Undergraduate Chemistry Researcher

University Of California, Berkeley, Francis Group

Berkeley, CA

Synthesis of semisynthetic porphyrin photosensitizer agents and phytopathogenic fungi cell targeting peptides and bioconjugation of the aforementioned photosensitizer agents and peptides to the MS2 virus capsid.

Jan 2015 - May 2016

Chemwiki Manager

Uc Davis

Managed a team of 11 employees through the process of writing and editing articles on undergraduate level general chemistry for the purpose of developing a competitive, free textbook alternative.

Sep 2013 - Aug 2014

Chemistry Tutor

Diablo Valley College

Pleasant Hill, CA

Tutored undergraduate students in general and organic chemistry.

Aug 2013 - Aug 2014

Lifeguard

Green Valley Pool

Danville, CA

Trained lifeguards in emergency management, public relations and CPR/First Aid skills. Ensured patron safety and satisfaction.

May 2013 - Sep 2013

Senior Lifeguard (Assistant Manager)

City Of San Ramon

San Ramon, CA

Assisted in the training of staff of 180 lifeguards in emergency management, public relations and CPR/First Aid skills. Managed teams of up to 16 lifeguards in order to ensure patron safety and satisfaction.

May 2007 - Jul 2011
Team & coworkers

Colleagues at REVOLUTION Medicines

Other employees you can reach at revolutionmedicines.com. View company contacts for 116 employees →

YL Yun Ling Yun Ling Colleague at Revolution Medicines South San Francisco, California, United States, United States View → BS Bethany Sawchyn Bethany Sawchyn Colleague at Revolution Medicines Elk River, Minnesota, United States, United States View → AE Allyn Eaker Allyn Eaker Colleague at Revolution Medicines Fremont, California, United States, United States View → HV Holly Vickery, Phd Holly Vickery, Phd Colleague at Revolution Medicines San Francisco Bay Area, United States View → RK Rebecca K. Rebecca K. Colleague at Revolution Medicines Menlo Park, California, United States, United States View → AS Ayathullah Syed Ayathullah Syed Colleague at Revolution Medicines Pleasanton, California, United States, United States View → MY Megan Yuen Megan Yuen Colleague at Revolution Medicines San Francisco Bay Area, United States View → JS John Setser Bs, Dabt John Setser Bs, Dabt Colleague at Revolution Medicines Bellville, Ohio, United States, United States View → DM David Montgomery David Montgomery Colleague at Revolution Medicines San Francisco Bay Area, United States View → VW Victoria Woodland Victoria Woodland Colleague at Revolution Medicines Cary, North Carolina, United States, United States View →
2 education records

Mark Tye education

Doctor Of Philosophy - Phd, Chemical Biology

Harvard University

Activities and Societies: Therapeutics Graduate ProgramDissertation: Development and mechanistic characterization of prolyl-tRNA.

FAQ

Frequently asked questions about Mark Tye

Quick answers generated from the profile data available on this page.

What company does Mark Tye work for?

Mark Tye works for REVOLUTION Medicines.

What is Mark Tye's role at REVOLUTION Medicines?

Mark Tye is listed as Medicinal Chemist at Revolution Medicines at REVOLUTION Medicines.

What is Mark Tye's email address?

AeroLeads has found 1 work email signal at @harvard.edu for Mark Tye at REVOLUTION Medicines.

Where is Mark Tye based?

Mark Tye is based in San Ramon, California, United States while working with REVOLUTION Medicines.

What companies has Mark Tye worked for?

Mark Tye has worked for Revolution Medicines, Harvard University, University Of California, Berkeley, Francis Group, Uc Davis, and Diablo Valley College.

Who are Mark Tye's colleagues at REVOLUTION Medicines?

Mark Tye's colleagues at REVOLUTION Medicines include Yun Ling, Bethany Sawchyn, Allyn Eaker, Holly Vickery, Phd, and Rebecca K..

How can I contact Mark Tye?

You can use AeroLeads to view verified contact signals for Mark Tye at REVOLUTION Medicines, including work email, phone, and LinkedIn data when available.

What schools did Mark Tye attend?

Mark Tye holds Doctor Of Philosophy - Phd, Chemical Biology from Harvard University.

What skills is Mark Tye known for?

Mark Tye is listed with skills including Chemistry, Organic Chemistry, Hplc, Biology, Mass Spectrometry, Spectroscopy, Bioconjugate Chemistry, and Biochemistry.

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