Michael Cochran Email & Phone Number

La Jolla, California

Developed novel antibody-oligonucleotide conjugates to treat rare muscle disorders. Developed analytical methods to characterize antibody-oligonucleotide conjugate purity and stability.Scaled antibody-siRNA conjugate production and purification from microgram scale for HTS to multi-gram scale for NHP studies.Managed manufacturing of oligonucleotide and antibody oligonucleotide conjugates, including technology transfer, process development, scheduling logistics, batch record review, change controls, review of validation protocols, and development of specifications.

Missoula, Montana Area

Developed, purified and characterized conjugates of small molecule adjuvants with protein antigens to support in vitro and in vivo preclinical studies.Prepared and characterized aqueous and nanoparticle formulations of poorly soluble novel adjuvants for in vitro and in vivo screening.Collaborated with team members from chemistry, formulations and immunology across multiple GSK sites to organize studies designed to evaluate new adjuvants and adjuvant-antigen conjugates.Analyzed data and presented results to team members and management.Participated in the writing of grants and patents.Prepared written monthly and semiannual reports for management.

Developed and characterized polymer ultrasound contrast agents containing chemotherapeutics and nucleic acids for ultrasound-triggered targeted drug and gene delivery. Examined biodistribution and drug delivery efficiency of drug loaded ultrasound contrast agents triggered with ultrasound in rat hepatocellular carcinoma model.Optimized ultrasound exposure parameters to improve gene delivery efficiency to cancer cells, endothelial cells and cardiomyocytes in vitro.Gained a strong understanding of cancer biology, microencapsulation techniques and polymer chemistry.Trained and supervised undergraduate biomedical engineering students.

Performed large scale DNA extractions to assist with TILLING, NUE, GLA and other projects.Designed primers for genotyping and quantitative PCR. Quantified expression of IFS1 and IFS2 in Glycine max.

Cultured mouse embryonic stem cells for directed pulmonary epithelial cell differentiation.Quantified expression of pulmonary epithelial cell markers. Used differentiated embryonic stem cells to recellularize rat tracheas.

Bs, Biomedical Engineering

Activities and Societies: American Institute of Chemical Engineers (AIChE)

Phd, Biomedical Engineering

Activities and Societies: International Society of Pharmaceutical Engineering (ISPE), Drexel Biomedical Graduate Student Association,