Matthew Boyce Email and Phone Number

Combining my knowledge of analytical chemistry and interest in software development to help expand EPA's web-based non-targeted analysis tools. Performing full-stack development of EPA's NTA web application to ease the analysis of complex chemical mixtures and help expand the application of NTA to wider audiences.

Combining in silico tools and non-targeted analysis to assess time-series metabolomic data

Analytical method development and validation for early phase pharmaceuticals

Thesis: Developing tools for paper-based cultures to interrogate oxygen’s role in cancer progressionProject 1: Developing oxygen-sensing optodes to map oxygen gradients in vitroPublication: Quantifying oxygen in paper-based cell culture with luminescent thin film sensorsThis work entailed:-Clean-room fabrication of oxygen-sensing thin films-Characterization, validation, and calibration of sensors in cell cultureProject 2: Engineering fluidic chips capable of imposing oxygen gradients across 3D culturesPublication: PendingThis work entailed:-Engineering inexpensive and simple-to-make fluidic chips for static 3D cell culture-Correlating cell location along an oxygen gradient to changes in hypoxic responseProject 3: Developing a paper-based tumor model to correlate local oxygen tension to cancer chemoresistancePublication: Assessing chemotherapeutic effectiveness using a paper-based tumor modelThis work entailed: -Culturing cells in 2D and 3D conditions-Developing new cell lines via transfection and transduction-Developing a bioassay to relate cell chemoresistance and regional oxygen tension-Optimizing and validating flow cytometric techniques to identify live/dead/senescent cells

TA of Analytical Research Techniques (graduate class)-Instructed 1 section of 4 students-Provided guidance on the integration of electronic circuits for use in analytical techniques-Developed and graded testsTA of Analytical Chemistry (undergraduate class)-Instructed 2 sections of 22 students-Lectured on a variety of analytical techniques -Graded lab reports and provided feedback in group and one-on-one settings