If something happens once, you cannot deny that it is real. Over-reliance on statistics ignores this. enofone (N of 1) was created as a way to understand complexity in biology. A way to characterize the exceptional. A way to understand what happens on the edge of robust networks. We are succeeding! We have a prophylactic and therapeutic regimen developed in a mouse model of head and neck cancer. To the extent that models reflect reality, we are closing in on elucidating a feature of the immune system that is almost certainly nearly universal. The word "agile" is insufficient to describe our approach. We do indeed "float like a butterfly, sting like a bee." We are open to all collaboration, thanks for checking us out. R.