Ricardo Morales Email & Phone Number

United States

Analytical Development

• Developed LC/MS/MS assays for compounds in plasma and other matrices, and conducted pharmacokinetic analyses to rank potential drug candidates • Bioanalytical laboratory lead to assure the pharmacokinetic studies proceeded according to established priorities• Analyzed over 460 PK studies annually with very low turnaround time• Improved laboratory procedures to streamline workflow and increase sample throughput; achieved a 2-fold increase in studies over a 3 year period with the same number of FTEs• Developed methods and conducted experiments in support of development candidates o Whole blood partitioning o Sample preparation methods to stabilize intermediate metabolites o Analysis of highly polar metabolites via a HILIC HPLC column in plasma and urine matrices across species • Collaborated studies between bioanalytical, medicinal chemistry and pharmacology • Demonstrated a highly proficient knowledge of quantitative analysis of drug compounds and instrumentation• Provided guidance and training to laboratory personnel

• Developed LC/MS/MS assays for quantitative analysis of drug and metabolite concentrations in different matrices to support pharmacokinetic and toxicokinetic studies• Processed and reported bioanalytical results to meet aggressive timelines which drove key decision making• Maintained laboratory and instruments to full functioning status• Presented concise and well organized data at research meetings• Helped prepare accurate technical reports, project summaries, protocols, and data compilation for patent submissions• Maintained a high level of data integrity and helped implement a formalized QC review system and research database

• Monitored and improved the quality of data to ensure laboratory meets or exceeds company standards• Routinely collaborated with laboratory manager and chemists to establish protocols to increase the efficiency of various metabolite separation assays using HPLC, GC, and LC/MS• Responsible for creating and accounting for the inventory of controls and standards used in the quantification of lipids and other metabolites• Experienced in assay and instrument troubleshooting• Assisted lab manager by leading/mentoring other chemists in daily laboratory functions• Trained laboratory technicians to maintain sufficient throughput and quality standards• Maintained a clear and orderly environment by performing routine maintenance of laboratory equipment, glassware, and supplies• Performed liquid-liquid and solid phase extractions from a variety of sample matrices (blood, plasma, serum, liver, urine, feces, skin, brain, and hair)• Utilized TLC and HPLC in the separation of metabolites• Prepared stock solutions• Integrated GC data with Chemstation• Acquired proficiency in lipid analysis