Ryan Mathews Email & Phone Number

San Diego, Ca, Us

Mascot, Sydney, Nsw, Au

Waltham, Ma, Us

LC, LC/MS, GC, GC/MS and application support

Riverview, Florida, Us

Certified instructor for Metrohm USA to train and certify field service engineers in basic and advanced courses for potentiometric titrations, Karl Fischer titrations (volumetric & coulometric), ion chromatography, voltammetry and automation and liquid handling for those technologies. Training includes applications, installations, IQ/OQ, data analysis, repairs, preventative maintenance and troubleshooting in each product line and compliance in non-regulatory and regulatory environments. Develop and create training collateral for courses.

Riverview, Florida, Us

Installation, IQ/OQ, customer training, instrument repair, instrument and application troubleshooting and method development/optimization of all product lines (ion chromatography, titration, Karl Fischer, voltammetry and NIRS) including configurations with automation and advanced liquid handling. Post-sales customer support troubleshooting instrumentation and application issues onsite and remotely, resolve escalations, method development/optimization and hardware repairs. Mentor and train field service engineers on various instrumentation, software, developing and programming methods and customer training.

Riverview, Florida, Us

Installation, IQ/OQ and training of ion chromatography systems for various applications and techniques. Techniques include partial loop, preconcentration, gradient, intelligent in-vial dilution, inline neutralization, combustion and multichannel systems using conductivity, UV-Vis, amperometric and mass spectrometry detection methods.Troubleshoot issues remotely and onsite and provide instrument repair and maintenance.

San Diego, California, Us

Research cancer cells acquired resistance to chemotherapy drugs and investigate the expression of copper efflux transporters ATP7A and ATP7B and resulting changes in vesicle acidification, multidrug resistance, endocytosis, signal transduction and the secretory pathway. Cell-based cytotoxicity assays using drug cocktails targeting multiple cellular proteins and pathways in cells containing copper binding proteins and cells with those proteins knocked out. Analyze protein and RNA expression levels in cells with and without copper binding enzymes using Western blot analysis and qRT-PCR as well as colocalization of proteins using immunocytochemistry and fluorescence microscopy.

Salt Lake City, Ut, Us

Medicinal chemistry research to develop selective peptide-based inhibitors for specific and highly homologous protein tyrosine phosphatases (PTPs). Determine selective peptide substrates of homologous PTPs by synthesizing combinatorial peptide libraries and screen for selective PTP substrates. Isolate specific peptide substrates for sequencing using partial Edman degradation and MALDI-TOF for peptide sequencing. Peptide synthesis, purification by HPLC and sequencing using MALDI-TOF mass spectrometry. Validate enzyme kinetics of PTP substrates using fluorescence spectroscopy plate reader.

Doctor Of Philosophy (Ph.D.), Analytical Chemistry | Bioinorganic Chemistry

Bachelor'S Degree, Chemistry