Simon Fletcher Email and Phone Number
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Highly motivated, innovative and collaborative scientist with 25 years of experience in virology and immunology, with broad experience in drug discovery and development. This includes:- Extensive experience developing research strategies, as well as leading discovery and supporting development of direct-acting antivirals and immunomodulatory agents. - More than 20 years of management and leadership experience in small biotech (Anadys), medium biopharma (Gilead) and large pharma (Roche); currently lead team of 40+ scientists.- Extensive virology experience, including hepatitis viruses (HBV, HCV, HDV), respiratory viruses (e.g., RSV, SARS-CoV-2) and herpesviruses (e.g., CMV, HSV).- Broad immunology experience, including discovery and development of diverse immune modulators (e.g., TLR agonists, checkpoint inhibitors, therapeutic vaccines).- Experience with discovering and developing novel agents with different modalities (small molecules, antibodies and other biologics, viral vector vaccines).- Experience supporting agents from early discovery through Phase 2 and various regulatory filings (IND, CTA, SCOTT, investigator brochures, product labels).- Extensive experience interacting with functions across biopharmaceutical organizations (e.g., research, clinical development, corporate development, commercial, regulatory, med affairs).- Extensive experience working with diverse external partners (CRO, biotech and pharma organizations, as well as academic groups). - Experience with in-licensing, acquisition and out-licensing deals.Specialties: virology; antivirals; immunology; innate immunity; immunotherapies; viral hepatitis; HBV; HCV; HDV; herpesviruses; CMV; HSV; RSV; COVID; SARS-CoV-2; pandemic preparedness; translational medicine; molecular biology; cell biology
Gilead Sciences
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- gilead.com
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Vice PresidentGilead Sciences May 2023 - PresentFoster City, Ca, Us- Lead team of ~45 focused on developing novel treatments for HBV, HDV, respiratory viruses, herpesviruses, neglected/emerging viruses, and viruses with pandemic potential.- Responsible for the strategy, portfolio, and budget for all non-HIV virology research- Played important role in various in-licensing/acquisition deals (e.g., MYR Pharmaceuticals, Hookipa Pharma, Novartis) across different viral indications.- Member of Gilead Research Leadership Team as well as the company-wide Operating Group.- Devised and led inter-disciplinary project that culminated in the discovery and development of selgantolimod (GS-9688), a toll-like receptor 8 (TLR8) agonist currently in phase 2 studies.- Gilead lead of collaborative team that identified function of HBV X protein (Nature publication) -
Executive DirectorGilead Sciences Aug 2018 - May 2023Foster City, Ca, Us -
Director, BiologyGilead Sciences Aug 2015 - Jul 2018Foster City, Ca, Us -
Principal ScientistGilead Sciences Apr 2012 - Jul 2015Foster City, Ca, Us -
Principal ScientistRoche Jan 2012 - Apr 2012Switzerland 🇨🇭 , Ch- Project leader of three inter-disciplinary drug discovery programs for HBV and HCV.- Led two strategy teams focused on immunomodulation and HBV, respectively, and was a key contributor to a year-long exercise identifying new research areas.- Discovery leader of an HBV experimental medicine team. Led and coordinated a translational research program comprising multiple academic collaborations and internal activities.- Devised new programs focusing on novel therapeutic targets for HBV and other viruses. - Devised and managed studies focused on understanding host-virus interactions utilizing state-of-the-art proteomic and genomic technologies. - Designed and managed MOA and combination studies for various HCV therapeutics.- Contributed immunology and biomarker expertise to HBV clinical teams.- Evaluated various in-licensing opportunities. Conducted a due diligence, provided risk assessment and devised and planned key preclinical efficacy and MOA studies.- Contributed to the microbiology sections of the Pegasys® and Copegus® label updates -
Senior ScientistRoche Nov 2009 - Dec 2011Switzerland 🇨🇭 , Ch -
Associate Research FellowAnadys Pharmaceuticals Aug 2009 - Nov 2009Us- Translational medicine leader for the ANA773 and ANA975 HCV programs. ANA773 and ANA975 activate host immunity via TLR7. - Project leader of a cross-functional discovery program, which included HTS against multiple targets and extensive lead optimization. Program produced a clinical candidate, ANA773.- Managed multiple IND-enabling preclinical activities for the ANA773 and ANA975 programs, including MOA, immunoprofiling, cytotoxicity, combination and cross-resistance studies.- Made significant contributions to a European CTA and two US IND filings.- Designed preclinical pharmacology studies with ANA773 and other TLR7 agonists to evaluate the impact of dose, dose schedule, route of administration and agonist structural class on pharmacodynamic and toxicologic responses.- Design, management, coordination and analysis of biomarkers for various toxicology studies and clinical trials (healthy volunteer, HCV and cancer patients) with ANA773.- Made substantial contributions to the strategic development of the TLR programs, including grant, contract and partnership proposals for asthma/allergy, biodefense and additional infectious disease indications, respectively.- Member and key contributor to the Anadys-Novartis co-development team for ANA975 -
Principal ScientistAnadys Pharmaceuticals Jan 2007 - Jul 2009Us -
Senior ScientistAnadys Pharmaceuticals Mar 2004 - Dec 2006Us -
ScientistAnadys Pharmaceuticals Oct 2001 - Feb 2004Us -
Post-Doctoral ScientistRoche Jul 1999 - Sep 2001Switzerland 🇨🇭 , Ch- Investigation of interferon-alpha mediated inhibition of HCV replication.- Development of a novel selectable HCV monocistronic replicon. -
ScientistCambridge Antibody Technology Jun 1998 - Jul 1999Us- Set up and optimization of the Ribosome Display methodology as a drug discovery tool.
Simon Fletcher Skills
Simon Fletcher Education Details
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University Of CambridgeVirology -
University Of CambridgeNatural Sciences (Biochemistry)
Frequently Asked Questions about Simon Fletcher
What company does Simon Fletcher work for?
Simon Fletcher works for Gilead Sciences
What is Simon Fletcher's role at the current company?
Simon Fletcher's current role is Vice President, Head of Hepatitis, Herpes, Respiratory and Emerging Viruses Research Group at Gilead Sciences.
What is Simon Fletcher's email address?
Simon Fletcher's email address is fl****@****aol.com
What is Simon Fletcher's direct phone number?
Simon Fletcher's direct phone number is +161925*****
What schools did Simon Fletcher attend?
Simon Fletcher attended University Of Cambridge, University Of Cambridge.
What skills is Simon Fletcher known for?
Simon Fletcher has skills like Drug Discovery, Immunology, Virology, Biomarkers, Drug Development, Assay Development, Molecular Biology, Clinical Development, Pharmacology, Clinical Trials, Cell Biology, Translational Medicine.
Who are Simon Fletcher's colleagues?
Simon Fletcher's colleagues are Ricky Fung, Amjath Sulaiman, Ashvir Bains, Stacey Eng, Carol Donoho, Bitna Yi, Han Ke.
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