Smruthi Ganesh Email & Phone Number

Redwood City, California, United States

Redwood City, California, United States

• Provided PM support for an early discovery project via organizing core team meetings, consolidating meeting minutes and framing agenda to facilitate key discussions for driving project strategy.
• Framed goals and conducted quarterly check-ins with the team to trach progress.
• Worked closely with project team leaders to identify key milestones and risks associated with project approaches.
• Worked with cross-functional representatives on the project to build timelines and decision trees for tracking activities and guide decision making.
• Provided support for the screening team by developing team meeting agendas and timelines facilitating completion of deliverables. Assay development and High throughput screening:
• Led the development of TR-FRET and Fluorescence Polarization assays which was used as the primary screen for multiple early-stage discovery projects to identify hits.

Redwood City, California, United States

Cambridge, Massachusetts, United States

• Led hit-triage efforts using biophysical assays to characterize protein and compounds for binding, aggregation and stability and developing alternative screening approaches.
• Contributed towards establishing a screening workflow for assaying both internal and external compound libraries.
• Streamlined screening workflows using automated liquid handlers (Bravo, Multidrop and Mosquito)
• Gained experience in data capture and reporting through weekly data analysis on Genedata and CDD platforms.
• Collaborated with other functional groups to deepen understanding on impact and to deliver periodic updates at both smaller project groups and drug discovery meetings.
• Trained with internal program managers to explore project management for career development.

Philadelphia, Pennsylvania

• Conducting high throughput small molecule screens to identify lead compounds that enhance mitochondrial function
• Characterizing worm models of Down Syndrome using RNAi for gene knockdown studies (Independent project)
• Culturing patient fibroblasts and performing multicolor FACS analysis to study physiological parameters
• Collaborating with cross functional teams to cross mutant C. elegans into reporter lines for quantifying fluorescence
• Liaising on mitochondrial research with pharmaceutical companies for conducting drug screens
• Responsible for writing manuscripts, protocols to support assay documentation and reagent preparation

• Optimized PCR conditions and designed primers while studying the transcriptional profile in latent HIV-1 using U1 promonocytic cell line as a model
• Cultured U1 and HEK293 cells, performed RNA extraction and TA cloning of HIV-1 PCR products
• Worked closely with fellow members to develop an understanding on plasmid construction, transfection of HEK293 cells by observing BSL-3 regulations

United States

• Conducted weekly recitations, prepared lectures, led discussions on Fundamentals of Physics
• Maintained a consolidated grade sheet and worked with fellow TAs to evaluate the progress of students

Thanjavur Area, India

• Assessed the antioxidant property of phenols from Cocos nucifera by performing colorimetric assays
• Optimized reaction conditions for solvent extraction using response surface methodology
• Analyzed the active fraction with high phenolic content by performing column chromatography and purification using HPLC

Pondicherry, India

• Executed cloning and transformation protocols in E. Coli and confirmed the expression of target gene using PCR

Thanjavur Area, India

• Studied synergistic interaction between antibiotics by performing MIC-MBC tests
• Carried out broth dilution, colony isolation, plating and performed biochemical tests all by using aseptic techniques

Master'S Degree, Infectious Disease, 3.79

Activities and Societies: Institute of Molecular Medicine and Infectious disease

Bachelor Of Technology - Btech, Biotechnology, First Class With Dinstinction

Activities and Societies: (1) DAKSH: Student-run Technical and/ or Management festival at SASTRA University (2) Biotikos: Student.