Sombeet Sahu Email & Phone Number

California, United States

South San Francisco, California, US

South San Francisco, California, US

South San Francisco, California, US

South San Francisco, California, US

• Early founding member at Mission Bio and a key contributor to the development of the Tapestry Single Cell multi-omics suite. Played a crucial role in engineering core platform modules and algorithms, contributing to.
• Devised multiple Deep Learning algorithms for single-cell multi-omics datasets, enhancing biological insight extraction. Invented/Patented several ML methods to significantly improve the signal-to-noise ratio in.
• Developed/Invented Transformer based DNA error correction module to correct instrument-specific PCR errors using semantic relationships. Improved variant calling sensitivity and specificity significantly.
• Improved doublet detection sensitivity by developing deep learning-based models and iterative training on millions of datasets. Implemented MLops pipelines to deploy production-ready models.
• Developed novel strategies and algorithms for stratifying tumor clones and analyzing tumor evolution, addressing single-cell data's unique challenges such as allele drop outs.
• Spearheaded the development and lifecycle management of ML models for customer-facing analysis products, including variant calling and error correction.

Waltham, MA, US

• Led the development of companion diagnostic tests, managing a group of three to deliver NGS-based IVDproduct solutions. This collaborative effort with Novartis and Pfizer played a critical role in achieving.
• Designed and implemented robust algorithms and pipelines to support projects across various applications,including Immuno-Oncology, Liquid Biopsy, Non-Invasive Prenatal Testing (NIPT), and Fusion Detection.
• Developed a scalable cloud infrastructure to facilitate bioinformatics and genomics research anddevelopment workflows.
• Created multiple analytical tools and visualization software to monitor and enhance assay performance aswell as to assess instrument and chip quality. Provided solutions for error correction that were adopted byboth.
• Conducted comprehensive analyses of system and assay performance, closely collaborating with thechemistry and panel design teams. These efforts were instrumental in refining experimental designs and optimizing assay.

Basel, Baselstadt, CH

• Engineered a comprehensive data analysis and visualization tool tailored for NIBR scientists, facilitating theexamination and tracking of numerous silencing experiments integrated with NGS data, thereby.
• Conceptualized and executed the development of a LIMS (Laboratory Information Management System)visualization tool, enabling the analysis of clinically significant markers within whole-genome and RNA-Seqdatasets, which.
• Performed in-depth analysis of bulk RNA sequencing datasets to identify key features and markers that aredifferentially expressed, providing valuable contributions to the understanding of genetic expression patterns.

Pittsburgh, PA, US

Statistical Modeling of Bioinformatics Data

Ms, Computational Biology, Biomedical Engineering

B Tech, Biotechnology, Bioinformatics