Victor Howard Email and Phone Number

Lead and supervise an in vivo technical team, ensuring the successful execution of study requests and providing meaningful design feedback, animal procurement, and study schedule coordination and prioritization to meet deadlines, averaging ~90 in vivo studies per year.Collaborate with cross-functional teams in a gene therapy research organization, focusing on adeno-associated virus (AAV) and non-viral interventions, to support and contribute to groundbreaking advancements in the fields of immunology targeting systemic disease states.Contribute to the Research and Technology operations leadership team by forecasting company needs, providing operational strategies, and delivering decision-making data to senior leadership through clear and open communication.Develop, present, and implement training guides for goal setting and career development for a 60-persondepartment, personalized in vivo career ladders, and a comprehensive cross-functional training plan for in vivo techniques, fostering the professional growth and development of team members.Actively participate as a voting member on the IBC committee for Spark Therapeutics and Rowan University, contributing to important decisions and ensuring compliance with ethical and safety standards.Serve as the primary contact and system administrator for tik@lab (A-Tune) vivarium management software, ensuring efficient and effective use of the system for seamless laboratory operations.Recognized as the 2023 Winner of the Roche Global 3Rs Award - 1st Place, Scientific, for outstanding contributions to the advancement of the principles of Replacement, Reduction, and Refinement in animal research.

Manage projects concerning obesity and diabetes therapeutics involving GIPR and long-acting Amylin to a candidate declaration/investment decision milestone, triggering IND pipeline activitiesTasked with foundational in vivo studies exploring potential combination therapies with AstraZeneca assets in the cardiovascular, renal, and metabolism space

In vivo pharmacologist responsible for managing characterization for multiple therapeutic targets in the Cardiovascular/Renal/Metabolic Disease group, on-site and utilizing CROsResponsibilities include coordinating with CVRM team members, technical staff, and pipeline candidate team members for the timely characterizations of potential therapeutics; safety point of contact for CVRM imaging instruments; technology onboarding for investigative tools like DSI's continuous glucose monitoring system in research modelsIn vivo Biology lead responsibilities include coordinating, communicating, and collating data for therapeutic team meetings and for senior research decision makingAttendance and participation at academic conferences to spread MedImmune 's work and brandIACUC Board Member (Voting)

Job responsibilities include management and coordination of the lab’s genetically modified mouse lines; design and implementation of in vivo diet and pharmacology studies; phenotyping of murine models of metabolic disease including glucose and insulin tolerance, DEXA body composition, and respiration and energy profiles via CLAMS system; tissue collection and preservation of study tissues for protein and RNA expression analysis; primary culture of myoblasts and assessment of mitochondrial function via Seahorse XF Flux assays; stocking lab supplies, maintaining lab equipment, and a majority of day-to-day general upkeep responsibilitiesHighlights include founding the laboratory – initial equipment purchases, authoring the laboratory’s Animal Ethics protocol for the Monash Animal Users Committee, authoring the laboratory’s State of Victoria license for usage with genetically modified organisms; maintaining multiple collaborations with investigators in Biochemistry and Anatomy at Monash University and Regeneron Pharmaceuticals; mentoring post-bac students and PhD candidates

Research Associate 4, 2009-2012 Played a central role in the development and characterization of hyperlipidemic murine models; Assessment of two triglyceride directed therapeutic targets via in vivo pharmacology; Serum lipid profile analysis via HPLC; Assessment of liver triglyceride content via organic extraction; Compiling data and authoring progress reports for Sanofi-Aventis sponsored projectsResearch Associate 3, 2006-2009 : Performed target validation of Regeneron humanized monoclonal antibodies; Development and characterized murine models of dislipidemia; Generated an in vitro LDLR-Dependant Uptake Assay to differentially screen therapeutic candidates; Successfully completed PCSK9 mAb campaign from idea to IND filing – currently in clinical trialsResearch Associate 2, 2004-2006 Performed second-tier metabolic phenotyping of selected GPCR KO Mice (Proctor and Gamble sponsored project); Performed internal metabolic assessments of Regeneron proprietary compounds; Assumed operations of internal serum chemistry core using the Bayer/Siemens ADVIA 1650

Charted changes in transcriptional factors in murine models of Huntington’s Disease

Investigated the clearance of A via passive antibody mediation in Alzheimer’s disease; Maintained, coordinated, and genotyped mouse colonies