Nathan Walsh Email & Phone Number

Cambridge, Massachusetts, Us

🔹 Drove innovation and efficiency by providing strategic guidance for the genomics department🔹 Prepared for future throughput and technologies by collaborating with cross-functional teams to integrate robotic plate handling and AI/ML tools into NGS Prep🔹 Managed a group of informatics scientists to build tools and analysis pipelines🔹 Improved time to result from 4 hr/run to 20 min/run with improved accuracy by leading a team of informatics scientists in developing advanced tools and analysis pipelines using nextflow parallelization🔹 Allowed searching and meta-experiment analysis of CRISPR Cas, DSB, Base Editors and Prime Editors by developoing a comprehensive registry for guide RNAs, nucleases, and amplicons🔹 Allowed existing workflows to communicate with new databases by building integrated SDKs🔹 Provided universal guides so that the same formulation of LNP's could be used across mouse, human, and NHP experiments through guidance and oversight to my team

Startup microfluidics manufacturer for automated sample-prep and PCR detection🔹 Brought technology to market as part of the Senior Team with CEO, CFO, and Head of Engineering🔹 Identified key markets are obstacles to uptake as a key liaison with Knowledge Leaders -Successfully released the MiQLab system for automated sample prep and qPCR🔹 Wrote python software for machine learning (AI) for bacterial detection, implemented required checks and automated builds of software before merging code changes🔹 Improved software testing/dev environments by rolling out the use of Docker images🔹 Successfully managed migration to AWS to store > 30 million records and > 4 million images while keeping data live and interactive and keeping current and projected AWS operational costs below $10/month🔹 Worked on FDA compliance for COVID-19 EUA until FDA restricted its approval process🔹 Brought 4 full panels to market (Bacterial-AMR, UTI, pathogenic GI, and Bioreactor)🔹 Brought Sensitivity from 500,000 down to <100 CFU/mL for biomedical testing🔹 Managed the growth and maintenance of 100's of different bacteria, protozoa, and fungi requiring BL2, import permits, and FDA/CDC approval for on-site storage and use of pathogens of concern

🔹 Turned a design into a working instrument by leading the Biology and Informatics teams🔹 Designed and evaluated applications (PCR assays) for multiple markets🔹 Focused company on Veterinary Health, where expectations matched throughput and performance -Wrote python software for bacterial detection, image analysis, instrument simulation, and the main dashboard for tracking runs on instruments across the country🔹 Worked jointly with the Engineering team to identify and fix weaknesses in the MiQLab system -Implemented a continuous improvement of existing panels and established pipeline for new panels -Designed and oversaw the development of more than 100 specific PCR tests🔹 Designed, implemented and maintained databases in both RDBMS and NoSQL on virtual servers and at AWS

Hercules, Ca, Us

Microfluidics device maker for next-generation sequencing with over 150 person staff🔹 Part of the Senior Team with full directional decision over the entire Cambridge site🔹 Leader of the Informatics team responsible for genomic analysis on and off instrument🔹 System Integration Liaison for medical device across all departments🔹 Built world class Informatics team through hiring, mentoring and building opportunities for my team🔹 Integrated the Informatics team from a silo into a core resource embedded in most projects🔹 Managed the building of identification, clustering, graph theory, and sequencing algorithms🔹 Increased from 50% to 90% the identification rate of microfluidic drops🔹 Drove the false positive rate from 20% to 1%🔹 Directed the building of tools and websites for ordering, manufacturing, in-house data analysis🔹 Developed a pipeline for DNA multiplex primer design and probe specificity

🔹 Manager of two CRO's (IT and DNA Sequencing)🔹 Formulate and oversee projects, timelines, deliverables of CRO's🔹 Implemented new computational methods to assign statistical significance to hits🔹 Devised and implemented new strategies for evaluating reproducibility and specificity of hits🔹 Generated lists of hits and presented results to Senior Management🔹 Designed DNA sequences compatible with “DNA Programmed Chemistry”🔹 Automated the processing of selection data from acquisition to hit lists🔹 Worked closely with Biologists and Informatics to create specific Oracle databases and user interfaces with embedded SQL🔹 Organized meetings and tracked progress of the Informatics team members🔹 Presented scientific results at external meetings🔹 In-house Software Requirement gathering, Development, and Production using C,C++,Perl, Python, Javascript, MATLAB or other languages as needed 🔹 Composed informatics and IT budget of >$500,000/year for a 30 person company🔹 Evaluated and managed the installation and maintenance of commercial software🔹 Purchased hardware and supervised installation and maintenance

Cambridge, Ma, Us

🔹 In charge of DNA sequence design for “DNA Programmed Chemistry”🔹 Translated data from Chemistry and Analytics to provide clear communication🔹 Set up inventory tracking and registration database and trained users🔹 Rolled out Electronic Lab Notebook (ELN) company wide🔹 In-house Chemistry Software Requirement gathering, Development, and Production🔹 Performed hardware installation and maintenance

Boston, Ma, Us

Managed a Synthetic Biology Project designed to construct an in vivo counter including supervison and training of a rotation PhD studentCoordinated a proteomic mass spec project and identified protein complexes

Us

Designed and implemented computational algorithms for identifying human enhancers using clustered microarray data

Ph.D., Biology (Biophysics)

Sc.B., Biochemistry