Complex Portal

The Complex Portal is primarily a manually curated, encyclopaedic resource of macromolecular complexes from a number of key model organisms. Complexes are defined as an assembly of any two or more proteins and/or nucleic acids that are stable enough in vitro to be reconstituted and have been demonstrated to have a specific molecular function. They may also contain small molecules if they are essential, functional components. In addition to the manually curated complexes, which adhere to this definition, the database provides extended coverage of the human complexome with high confidence assemblies of machine-learning predicted complexes. All manually curated complexes are derived from physical molecular interaction evidences extracted and cross-referenced from the literature and cross-referenced to the Molecular Interaction Database IntAct where available, or by curator inference from information on homologs in closely related species or by inference from scientific background. All manually curated complexes are tagged with Evidence and Conclusion Ontology codes to indicate the type of evidence available for each entry.