Pharmacogenomics Global Research Network (Pgrn)

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The mission of the Pharmacogenomics Global Research Network is to catalyze and lead research in precision medicine for the discovery and translation of genomic variation influencing therapeutic and adverse drug effects.

Company Details

Employees
12
Address
Of Public Health Genomics At The Cdc
Industry
Medical Practices
NAICS
Ambulatory Health Care Services
Offices of Other Health Practitioners
Outpatient Care Centers
Other Ambulatory Health Care Services
Offices of All Other Health Practitioners
Outpatient Mental Health and Substance Abuse Centers
All Other Ambulatory Health Care Services
Offices of Podiatrists
Blood and Organ Banks
All Other Miscellaneous Ambulatory Health Care Services
Website
https://www.pgrn.org
Keywords
PGx, Precision Medicine, Pharmacogenomics, Pharmacogenetics, Pharmacology.
Competitors
PharmGKB, Egyptian society of pharmacogenomics and personalized medicine, College of Pharmaceutical Sciences & Drug Manufacturing, UK Pharmacogenetics and Stratified Medicine Network (UKPGx), Datum, Pharmacogenomics Access & Reimbursement Coalition, Clinical Pharmacogenetics Implementation Consortium, PharmaGenoXfE, American Society for Clinical Pharmacology & Therapeutics, Pharmacogenomics LLC.
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News

2026 Projected Global Resettlement Needs (PGRN) - UNHCR - The UN Refugee Agency

2026 Projected Global Resettlement Needs (PGRN) UNHCR - The UN Refugee Agency

Excessive expression of progranulin leads to neurotoxicity rather than neuroprotection - ScienceDirect.com

Excessive expression of progranulin leads to neurotoxicity rather than neuroprotection ScienceDirect.com

Empowering the pharmacogenomics research community with long-read sequencing - PacBio

Empowering the pharmacogenomics research community with long-read sequencing PacBio

Parkin Levels Decrease in Fibroblasts With Progranulin (PGRN) Pathogenic Variants and in a Cellular Model of PGRN Deficiency - Frontiers

Parkin Levels Decrease in Fibroblasts With Progranulin (PGRN) Pathogenic Variants and in a Cellular Model of PGRN Deficiency Frontiers

Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice | EMBO reports - EMBO Press

Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice | EMBO reports EMBO Press

PGRN Inhibits Early B-cell Activation and IgE Production Through the IFITM3-STAT1 Signaling Pathway in Asthma - Wiley

PGRN Inhibits Early B-cell Activation and IgE Production Through the IFITM3-STAT1 Signaling Pathway in Asthma Wiley

Deciphering the potential role of PGRN in regulating CD8+ T cell antitumor immunity | Cell Death Discovery - Nature

Deciphering the potential role of PGRN in regulating CD8+ T cell antitumor immunity | Cell Death Discovery Nature

Selective neuronal expression of progranulin is sufficient to provide neuroprotective and anti-inflammatory effects after traumatic brain injury - Journal of Neuroinflammation

Selective neuronal expression of progranulin is sufficient to provide neuroprotective and anti-inflammatory effects after traumatic brain injury Journal of Neuroinflammation

Progranulin as a therapeutic target in neurodegenerative diseases - ScienceDirect.com

Progranulin as a therapeutic target in neurodegenerative diseases ScienceDirect.com

Progranulin inhibits autophagy to facilitate intracellular colonization of Helicobacter pylori through the PGRN/mTOR/DCN axis in gastric epithelial cells - Frontiers

Progranulin inhibits autophagy to facilitate intracellular colonization of Helicobacter pylori through the PGRN/mTOR/DCN axis in gastric epithelial cells Frontiers

Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis - Nature

Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis Nature

Progranulin from different gliocytes in the nucleus accumbens exerts distinct roles in FTD- and neuroinflammation-induced depression-like behaviors - Journal of Neuroinflammation

Progranulin from different gliocytes in the nucleus accumbens exerts distinct roles in FTD- and neuroinflammation-induced depression-like behaviors Journal of Neuroinflammation

Hepatocyte-macrophage crosstalk via the PGRN-EGFR axis modulates ADAR1-mediated immunity in the liver - ScienceDirect.com

Hepatocyte-macrophage crosstalk via the PGRN-EGFR axis modulates ADAR1-mediated immunity in the liver ScienceDirect.com

An anti-sortilin affibody-peptide fusion inhibits sortilin-mediated progranulin degradation - Frontiers

An anti-sortilin affibody-peptide fusion inhibits sortilin-mediated progranulin degradation Frontiers

Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology - Nature

Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology Nature

Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic - ScienceDirect.com

Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic ScienceDirect.com

PGRN acts as a novel regulator of mitochondrial homeostasis by facilitating mitophagy and mitochondrial biogenesis to prevent podocyte injury in diabetic nephropathy | Cell Death & Disease - Nature

PGRN acts as a novel regulator of mitochondrial homeostasis by facilitating mitophagy and mitochondrial biogenesis to prevent podocyte injury in diabetic nephropathy | Cell Death & Disease Nature

Progranulin and Its Receptor Predict Kidney Function Decline in Patients With Type 2 Diabetes - Frontiers

Progranulin and Its Receptor Predict Kidney Function Decline in Patients With Type 2 Diabetes Frontiers

Progranulin (PGRN) expression in ALS: An immunohistochemical study - ScienceDirect.com

Progranulin (PGRN) expression in ALS: An immunohistochemical study ScienceDirect.com

Progranulin Adsorbs to Polypropylene Tubes and Disrupts Functional Assays: Implications for Research, Biomarker Studies, and Therapeutics - Frontiers

Progranulin Adsorbs to Polypropylene Tubes and Disrupts Functional Assays: Implications for Research, Biomarker Studies, and Therapeutics Frontiers

Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons - Molecular Neurodegeneration

Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons Molecular Neurodegeneration

Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration - Molecular Neurodegeneration

Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration Molecular Neurodegeneration

Anti-sortilin1 Antibody Up-Regulates Progranulin via Sortilin1 Down-Regulation - Frontiers

Anti-sortilin1 Antibody Up-Regulates Progranulin via Sortilin1 Down-Regulation Frontiers

CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline | EMBO Molecular Medicine - EMBO Press

CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline | EMBO Molecular Medicine EMBO Press

TNFR2/14-3-3ε signaling complex instructs macrophage plasticity in inflammation and autoimmunity - JCI.org

TNFR2/14-3-3ε signaling complex instructs macrophage plasticity in inflammation and autoimmunity JCI.org

Progranulin Administration Attenuates β-Amyloid Deposition in the Hippocampus of 5xFAD Mice Through Modulating BACE1 Expression and Microglial Phagocytosis - Frontiers

Progranulin Administration Attenuates β-Amyloid Deposition in the Hippocampus of 5xFAD Mice Through Modulating BACE1 Expression and Microglial Phagocytosis Frontiers

Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice - Molecular Neurodegeneration

Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice Molecular Neurodegeneration

Pharmacogenomics at the Tipping Point: Challenges and Opportunities - Wiley

Pharmacogenomics at the Tipping Point: Challenges and Opportunities Wiley

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