Aaron Blanchard

Aaron Blanchard Email and Phone Number

Postdoctoral Scholar @ Duke University
Durham, NC, US
Aaron Blanchard's Location
Durham, North Carolina, United States, United States
About Aaron Blanchard

I have a ten-year track record as a protein and nucleic acid engineer/scientist. Engineer because I am intrinsically passionate about technological development, and scientist because I drawn to understanding why biomolecular technology behaves the way that it does. I thrive with projects that allow me to balance big new ideas with deep in-the-weeds technical thought. I'm a fan of using computational approaches in ways that synergize with bench-work to increase throughput and information depth. I love collaboration and excel at written, oral, and visual technical communication. I am also passionate about equity and inclusion and have served on my departments' DEI committees throughout my postdoctoral studies.As a postdoctoral scholar at Duke University and an NIH K00 fellow, I have been developing new linker domains for fusion protein engineering purposes. Fusion proteins, which are composed of two or more proteins stitched together, can be powerful tools for targeting and manipulating biological systems. Their performance can depend heavily on the choice of linker peptide that is used to connects the two proteins. My work aims to expand the repertoire of linker options and optimize their properties for various applications. I have a PhD from Georgia Tech and Emory University where I developed next-generation assays for molecular detection, as well as DNA-based structures that generate, sense, and transmit piconewton-scale mechanical forces. When added to a one-year postdoc at the University of Michigan, I have six years experience developing DNA nanotechnology. I have technical expertise in microscopy, molecular analytical techniques, and coding.

Aaron Blanchard's Current Company Details
Duke University

Duke University

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Postdoctoral Scholar
Durham, NC, US
Aaron Blanchard Work Experience Details
  • Duke University
    Postdoctoral Scholar
    Duke University
    Durham, Nc, Us
  • Duke University
    Postdoctoral Scholar
    Duke University Sep 2021 - Present
    Durham, North Carolina, United States
    Brent Hoffman group, Department of Biomedical Engineering.A fusion protein is made by taking two proteins and "fusing" them together via a protein linker. Imagine taking a protein that binds to cancer and fusing it to a protein that binds to an immune cell. Research consistently shows that your choice of protein linker can have an enormous effect on your fusion protein's function. But there are few linkers to choose from when building your fusion protein - I estimate that 3-4 linkers are used in ~90% of applications. My work has focused on the development of new linkers for use in fusion protein design, as well as novel methods for screening large numbers of fusion proteins for linker optimization.
  • University Of Michigan Biomedical Engineering
    Postdoctoral Scholar
    University Of Michigan Biomedical Engineering Aug 2020 - Aug 2021
    During my year in the laboratory of Nils Walter, I developed and screened a library of DNA nanodevices for optical probe optimization. I also developed technology (patent pending) for single molecule nucleic acid detection in partnership with a pre-established startup (aLight Sciences). Building on my PhD expertise, I performed routine single-molecule fluorescence microscopy, surface chemistry, and molecular analysis assays. I published one first-author paper (Nano Letters) and a second co-authored paper (Biosensors and Bioelectronics). One additional manuscript is in preparation.
  • The Wallace H. Coulter Department Of Biomedical Engineering At Georgia Tech And Emory University
    Graduate Research Assistant
    The Wallace H. Coulter Department Of Biomedical Engineering At Georgia Tech And Emory University Aug 2015 - Jul 2020
    Atlanta, Georgia, United States
    As a Biomedical Engineering PhD student in the lab of Dr. Khalid Salaita, I developed nucleic acid nanotechnology for biomolecular sensing and basic science research. Some highlights of my time include:• Managed, collaborated on, and completed over a dozen of research projects in the biomolecular sciences• Performed hundreds of hours of microscopy and image processing• Performed over a thousand hours of coding for data processing and modeling• Honed scientific writing and figure-making skills through authorship of ~20 papers in journals including Science and Nature Methods. • Extensive experience analyzing DNA and protein sequences using software (e.g. Benchling, Nupack, IDT, MATLAB), manual methods, and custom-written code• Substantial experience with DNA and protein conjugation methods (e.g. NHS-amine, click, silane, gold-thiol)• Performed HPLC, cell culture, and protein analytical techniques• Directly mentored several junior researchers• Completed TAships, a preparing future faculty program, and a teaching certificate program• Completed the department's graduate leadership program• Won the prestigious and highly competitive Suddath Memorial Award, the universities' top award for outstanding bioscience research• Won 3rd Place at the national collegiate inventors competition with presentation of RoloSense technologyMy thesis is titled "DNA Mechanotechnology for Sensing and Generating Piconewton Scale Mechanical Forces." I wrote an accessible description of this exciting research field for the journal Science titled "Emerging uses of DNA mechanical devices".
  • Powershift Group
    Nanotechnology Market Research Associate
    Powershift Group Oct 2014 - Dec 2014
    Austin, Texas Area
    • Conducted market research to identify market-leading products within various industries• Assembled database of nanotechnology leaders in agrictulture, food, oil, and environmental remediation sectors.
  • Ut Southwestern Medical Center
    Summer Undergraduate Research Fellow
    Ut Southwestern Medical Center Jun 2014 - Aug 2014
    Dallas/Fort Worth Area
    Principal Investigator: Jinming Gao• Evaluated structure-function relationship of potential anti-pancreatic cancer drug and analogs• Conducted animal studies and in vitro red blood cell assay to assess and mitigatemethemoglobinemia side-effect of substrate
  • The University Of Texas At Austin
    Undergraduate Research Assistant
    The University Of Texas At Austin Jan 2013 - May 2014
    Austin, Texas Area
    Principal Investigator: Nicholas Peppas• Characterized swelling behavior of pH and temperature-sensitive polyacrylamide hydrogels (one second author publication).• Improved biocompatibility of polyacrylamide nanoparticles by surface conjugation of PEG chains
  • Department Of Biomedical Engineering
    Tutor And Teaching Assistant
    Department Of Biomedical Engineering Aug 2012 - May 2014
    Ut Campus
    Accross three separate positions, I tutored and TA'd freshmen and sophomore level biomedical engineering and chemistry coursework in both group and one-on-one settings.
  • University Of Texas At Austin
    Resident Assistant
    University Of Texas At Austin Jul 2012 - May 2014
    Roberts Dormitory
    Live-in residential assistant for two-years.

Aaron Blanchard Education Details

Frequently Asked Questions about Aaron Blanchard

What company does Aaron Blanchard work for?

Aaron Blanchard works for Duke University

What is Aaron Blanchard's role at the current company?

Aaron Blanchard's current role is Postdoctoral Scholar.

What schools did Aaron Blanchard attend?

Aaron Blanchard attended Georgia Institute Of Technology & Emory University, The University Of Texas At Austin.

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