I was responsible for managing and executing the clinical genomics group strategy within the Clinical Biomarkers Discovery and Development (CBDD) organization of Medical Sciences. I worked closely with groups in multiple therapeutic areas and the current Biomarker group using microarrays and next-generation sequencing to advance the Amgen pipeline and inform the Biomarker Group for decisions around molecular analysis of clinical samples.• Managed budget for genomics experiments… Show more I was responsible for managing and executing the clinical genomics group strategy within the Clinical Biomarkers Discovery and Development (CBDD) organization of Medical Sciences. I worked closely with groups in multiple therapeutic areas and the current Biomarker group using microarrays and next-generation sequencing to advance the Amgen pipeline and inform the Biomarker Group for decisions around molecular analysis of clinical samples.• Managed budget for genomics experiments, including sourcing reagents, sample procurement, and FTE costs for biomarker programs supporting early pipeline objectives.• Productively collaborated with all therapeutic biomarker leads across multiple sites for design, execution, and analysis of genomics experiments• Presented genomics road-shows to Medical Sciences functions to inform decisions as to what experiments were appropriate to perform in-house.• Served as internal genomics expert to inform outsourcing decisions for multiple biomarker programs supporting the Amgen pipeline.• Qualified multiple genomic platforms (Ion Torrent PGM/S5, Illumina MiSeq, Nanostring nCounter) and author methods for assaying Amgen clinical trial samples.• Performed genomics experiments in the laboratory setting and remaining current with all required compliance programs. Show less

I evaluate and optimize new technologies for transcriptional and genomic analysis, while supporting the Clinical Biomarker - Oncology group's primary mission, providing quality and timely data to inform biomarker discovery and development.• Evaluation of nucleic acid preparation methods from all tissue types utilizing manual and automated methods, including quantification and quality control for all downstream processes.• Performance of next-generation sequencing across multiple… Show more I evaluate and optimize new technologies for transcriptional and genomic analysis, while supporting the Clinical Biomarker - Oncology group's primary mission, providing quality and timely data to inform biomarker discovery and development.• Evaluation of nucleic acid preparation methods from all tissue types utilizing manual and automated methods, including quantification and quality control for all downstream processes.• Performance of next-generation sequencing across multiple platforms, including the Ion Torrent Personal Genome Machine and the Illumina MiSeq instruments.• Performance and optimization of aCGH platforms to ascertain copy number variations across multiple sample types, including FFPE-archived and cell-free DNA.• Interrogation of Gene Expression Profiling and Copy Number Analysis using the Nanostring platform for problematic samples.• Authorship of SOPs for assaying clinical samples and downstream workflows.• Data quality control, integration of downstream analysis pipelines and archiving methodologies, and sample LIMS annotation schemes using both servers and cloud-based methods. • Developing reports and presenting to collaborators, clients, and national meetings. Show less