Dave Jacobs Email & Phone Number

1112 Church Street, Huntsville, Al 35801

GC, GPC, HPLC, NMR, Q-TOF MS, method development and validation

Streamlined the process of characterization, purification and distribution of synthetic organic compounds by absorbing the partial or complete functions of five colleagues, freeing others to work on special projects and reducing departmental outlay on headcount.Used robotic liquid handling systems and multiplexed HPLC/MS in high throughput characterization and purification of newly synthesized candidate APIs.Finished construction, directed programming and initiated operation of… Show more Streamlined the process of characterization, purification and distribution of synthetic organic compounds by absorbing the partial or complete functions of five colleagues, freeing others to work on special projects and reducing departmental outlay on headcount.Used robotic liquid handling systems and multiplexed HPLC/MS in high throughput characterization and purification of newly synthesized candidate APIs.Finished construction, directed programming and initiated operation of a salt selection/stable form screening system composed of a robotic liquid handler and PXRD unitUsed HPLC, PXRD, DVS, TGA, DSC, cIEF, and dissolution analyzer to evaluate purity and physical characteristics of candidate APIs; HPLC method development. Developed and implemented ELISAs for CTX-1 and osteocalcin to track bone remodeling in laboratory test animals’ sera.Established productive relationships with vendors, CROs, shippers and customs officials to coordinate shipping, receiving, distribution, testing and storage of biologic APIs. Show less

Developed enzyme assay that led to NIH funding, produced and purified substrates and antibodies, generated transgenic C. elegans strains for in situ hybridization and fluorescence microscopy. DNA purification, PCR, sequencing, subcloning and site-directed mutagenesis; SDS-PAGE, western blots.Assay/protocol development, data analysis, oral presentations, radiation safety officer, maintenance of plasmid database and frozen stocks, ordering supplies, coordination of equipment service.