Co-Investigator
CurrentA Review of How Adult and Pediatric Patients Die from High-Grade Glioma: This retrospective study aims to identify specifically how patients with high-grade gliomas (HGG) die. To date, there is limited literature that describes the specific pathophysiologic mechanisms by which children, adolescents and adults die from high-grade glioma, such as via primary brain failure, herniation, infection, etc. Here, we aim to perform a retrospective chart and imaging review in a deceased HGG patient population to better understand the pathophysiology of tumor progression that leads to death. To accomplish this goal, we will gather demographic, treatment, outcome, and imaging through prior to and at the time of death via chart review of a pre-determined HGG patient population in the adult and pediatric populations, all of whom have been primarily treated at the University of Michigan. We will compare disease characteristics within the adult and pediatric populations to determine the most common probable cause of death.