I am a BHF Intermediate Research Fellow with an interest in obesity-associated cardiometabolic disorders, including type 2 diabetes, hypertension and heart failure. I obtained my undergraduate degree in Immunology from the University of Edinburgh before undertaking a PhD at the Centre for Cardiovascular Science with Prof Ruth Andrew examining the role of glucocorticoid metabolism on inflammation. In 2012, I moved to the Integrative Biology and Pharmacology Department at the University of Texas Health Science Center Houston to continue my Postdoctoral training with Prof Rebecca Berdeaux. Here I identified a novel role for the AMPK-related kinase SIK1 in regulating glucose homeostasis in obesity.In 2014, I joined Prof Brian Walker’s group at the Centre for Cardiovascular Science in Edinburgh and demonstrated a novel role for the transmembrane exporter ABCC1 in regulating adipose tissue glucocorticoid exposure. In 2018, I was awarded a BHF Basic Science Intermediate Research Fellowship to establish my own group in Edinburgh investigating the contribution of CBG cleavage to adipose glucocorticoid delivery in obesity. My lab harnesses the power of pre-clinical models of obesity and glucocorticoid-induced cardiometabolic dysregulation, together with translational approaches in humans, to better understand the underlying pathologies of cardiometabolic complications and to seek out better therapeutic approaches. For more information on my team's research, visit our website:https://www.edinburghmetabolism.co.uk/mark-nixon