Michael Wolfe Email & Phone Number

Tallahassee, Fl, Us

Madison, Wi, Us

Madison, Wisconsin Area

• Led analyses of diverse and complex NGS experiments by coordinating with bench-level experimentalists to combine cutting-edge literature-based algorithms with custom code and provide insight for on-going experimental design and assay development.• Designed and implemented reproducible data analysis pipelines using Snakemake and custom Python code for several popular genomics techniques including ChIP-seq, RNA-seq, DNA-seq, and Hi-C to be used by non-experts and scale from desktop… Show more • Led analyses of diverse and complex NGS experiments by coordinating with bench-level experimentalists to combine cutting-edge literature-based algorithms with custom code and provide insight for on-going experimental design and assay development.• Designed and implemented reproducible data analysis pipelines using Snakemake and custom Python code for several popular genomics techniques including ChIP-seq, RNA-seq, DNA-seq, and Hi-C to be used by non-experts and scale from desktop computers to queue-controlled high-performance (HPC) computing systems.• Managed and maintained several data projects at once through interdisciplinary collaboration with experimentalists within the same lab, across the university, and at institutions across the country by translating key data insights into experimental guidance through written reports and oral presentations.• Developed and optimized novel next-generation sequencing assays for measuring transient nucleic acid structures in living bacterial cells at the bench, thoroughly documenting progress in well-maintained lab notebooks and producing reproducible experimental protocols.• Mentored and advised eight early-career scientists resulting in the success of five co-authored publications, six funded grant applications, one successful faculty search, and one undergraduate research thesis.• Demonstrated scientific communication expertise through weekly mentoring of scientists at several levels, monthly internal oral presentations, yearly attendance and presentation at national scientific conferences, and an average of one peer-reviewed publication per year.• Worked with key decision-makers to steer design of internal LIMS-like system for data sharing and management.• Bolstered project management and leadership expertise through eighteen hours of leadership training in the Postdoctoral Training Course in Scientific Leadership. Show less

Madison, Wisconsin, United States

• Coordinated and co-led interdisciplinary teaching team of eight graduate and postdoctoral instructors and sixteen undergraduate peer leaders to teach the fundamentals of biology in a highly interactive active learning classroom for underrepresented students in STEM.• Designed and developed teaching materials for a semester-long course using inclusive teaching principles that synergized with the rest of the teaching team and built community among learners.• Used project… Show more • Coordinated and co-led interdisciplinary teaching team of eight graduate and postdoctoral instructors and sixteen undergraduate peer leaders to teach the fundamentals of biology in a highly interactive active learning classroom for underrepresented students in STEM.• Designed and developed teaching materials for a semester-long course using inclusive teaching principles that synergized with the rest of the teaching team and built community among learners.• Used project management expertise to maximally support students and ensure teaching team taught and graded equitably. Show less

Ann Arbor, Mi

• Designed, developed, and implemented custom Python software together with custom visualization scripts in R to interrogate interactions between proteins and nucleic acids using next-generation sequencing data in human and bacterial cells.• Managed and maintained collaborations with wet-lab scientists to translate experimental problems into computational solutions to drive projects forward into four well-cited peer reviewed publications.• Applied Bayesian and frequentist… Show more • Designed, developed, and implemented custom Python software together with custom visualization scripts in R to interrogate interactions between proteins and nucleic acids using next-generation sequencing data in human and bacterial cells.• Managed and maintained collaborations with wet-lab scientists to translate experimental problems into computational solutions to drive projects forward into four well-cited peer reviewed publications.• Applied Bayesian and frequentist regression modeling together with machine learning approaches to understand key sequence-based drivers of important post-transcriptional regulators in humans.• Developed custom software in Python and Rust to determine predictive motifs of protein binding in biophysical parameters of DNA shape.• Maintained a cohesive lab and department culture through involvement in graduate recruiting, acting as a student representative at faculty meetings, and implementing a monthly computational biology learning group.• Demonstrated scientific communication skills through monthly internal oral presentations, yearly presentations at national scientific conferences, and public science communication through the Detroit Zoo Fellowship in Science Communication. Show less

Ann Arbor, Michigan, United States

• Designed and taught six one-hour introductory biochemistry lectures to first year medical students at Yirgalm Medical College in Ethiopia as part of the Ethiopia-Michigan Platform of Advancing Collaborative Engagement (EM-PACE).• Developed problem sets and facilitated one hour discussion sections for a first-year nursing course in chemistry. Held well-attended and interactive office hours where I led collaborative problem-solving sessions for >60 students at once.• Taught… Show more • Designed and taught six one-hour introductory biochemistry lectures to first year medical students at Yirgalm Medical College in Ethiopia as part of the Ethiopia-Michigan Platform of Advancing Collaborative Engagement (EM-PACE).• Developed problem sets and facilitated one hour discussion sections for a first-year nursing course in chemistry. Held well-attended and interactive office hours where I led collaborative problem-solving sessions for >60 students at once.• Taught graduate and post-doctoral peers to use computational methods to solve experimental problems as an instructor for Software Carpentry, a peer tutor for graduate students, and as the sole Graduate Student Instructor for a Foundations of Bioinformatics and Systems Biology course designed to interactively teach computational biology to non-specialists. Show less

Columbus, Ohio Metropolitan Area

• Managed and led two independent research projects focused on using in vitro biochemistry to characterize substrate-specificity for human tRNA modification enzymes.• Gained expertise in molecular cloning, protein purification, enzyme kinetics, and use of radio-labeled nucleic acids for activity assays.• Demonstrated time management and project management by balancing lab responsibilities with a full interdisciplinary engineering course-load and additional molecular biology… Show more • Managed and led two independent research projects focused on using in vitro biochemistry to characterize substrate-specificity for human tRNA modification enzymes.• Gained expertise in molecular cloning, protein purification, enzyme kinetics, and use of radio-labeled nucleic acids for activity assays.• Demonstrated time management and project management by balancing lab responsibilities with a full interdisciplinary engineering course-load and additional molecular biology coursework needed for a minor in biochemistry.• Drove two engineering projects as part of interdisciplinary teams including the design of a self-sustaining aquaponics system for implementation in rural Honduras, and the design of a exercise harness for use on the International Space Station in collaboration with Glenn Research Center of NASA.• Presented my work at five local and four national conferences and published an Undergraduate Honors Research Thesis. Show less

• Taught freshman physics, chemistry, and math utilizing one-on-one instruction methods• Promoted and imparted key problem solving and study skills in first-year college students

Doctor Of Philosophy (Ph.D.), Biochemistry

Thesis Title: Regulation of Gene Expression Through Nucleic Acid Binding Proteins: New Paradigms, Perspectives, and Tools. Advisor: Dr..

Master Of Science (M.S.), Bioinformatics

Courses - Applied Biostatistics, Signal Processing and Machine learning, Genomic and Epigenomic Data analysis, Statistical Com- puting.

Bachelor Of Science (B.S.), Biomedical Engineering

Magna cum laude, Minor in Biochemistry, With Honors in Engineering and Honors Research Distinction in Biochemistry Honors Thesis Title.

High School Diploma