The search for new products like natural molecules is at the heart of industrial needs and has an advantage in formulation. Through better knowledge of the chemical structure, the design of molecules requires mastering the tools of synthesis, purification, extraction correlated with analysis techniques. The complexity of the biological matrix and the different interactions within the cell require the implementation of strategies to better understand the chemistry-biology interaction. The current research projects cover :-Small Molecules: Synthesis, Full Characterization, Biological activity : Structure-Activity Relationship-Clay Minerals and Organosilicates : Formulation, Emulsion stabilization, Drug Delivery and Modeling -Smart (Stimuli-Responsive) Polyacrylamid Polymers: Synthesis, Characterization and Aging Mechanisms-Comparison of the taxonomic profile of the skin flora and Acne-Melanoma and Targeted Therapy